The Journal of Alternative and Complementary Medicine 2019

A randomized, double-blind, placebo-controlled pilot trialinvolving 67 subjects aged 25-60 years old, was conductedover 8 weeks to confrm the efcacy ofCQR-300 inreducing body fat.Key Findings:eSupports decreases in body fat measured by DEXA*Supports healthy adiponectin levels, a hormone thatregulates fat metabolismlmproves cholesterol and triglyceride levels*
Source: The Use of a Stem and Leaf Aqueous Extract ofCissus Quadrangularis (CQR-300) to Reduce Body Fat andOther Components of Metabolic Syndroms in OverweightParticipants

The Journal of Alternative and Complementary Medicine 2019
A randomized, double-blind, placebo-controlled pilot trialinvolving 67 subjects aged 25-60 years old, was conductedover 8 weeks to confrm the efcacy ofCQR-300 inreducing body fat.
Key Findings:
Supports decreases in body fat measured by DEXA*Supports healthy adiponectin levels, a hormone thatregulates fat metabolism*
lmproves cholesterol and triglyceride levels*Source: The Use of a Stem and Leaf Aqueous Extract ofCissus Quadrangularis (CQR-300) to Reduce Body Fat andOther Components of Metabolic Syndroms in OverweightParticipants

Journal: Natural Product Communications (NPC) 2015
A randomized, double-blind, placebo-controlled studyinvolving 61 participants aged 19-55 years old, was conductedover 8 weeks to test the efcacy of CQR-300 in improvingmetabolic parameters in participants with a BMl >28.
Key Findings:
Supports improved waist and hip circumference*eSupports healthy blood pressure and blood sugar levels*Supports increases in HDL(good) cholesterol*
Source: The use of cissus quadrangularis (CQR-300) in themanagement of components of metabolic syndrome inoverweight and obese participants

Journal: Lipids in Health and Disease 2008
A randomized double-blind placebo-controlled involving 72participants aged 21-44 years old, was conducted for 10weeks to evaluate the effects of combining CQR-300 with1GOB131 on weight loss.
Key Findings:
Supports up to a 20% reduction in body fat*eSupports up to 31% decrease in blood glucoseSupports up to a 44% decrease in total cholesterol*Source: The use of a cissus quadrangularis/irvingia gabonensiscombination in the management of weight loss: double-blind,placebo-controlled study

Lipids in Health and Disease 2006
A randomized, double-blind, placebo-controlled studyinvolving 123 participants aged 19-50 years old, wasconducted for 8 weeks to investigate the use of CQR-300in the management of certain metabolic factors.
Key Findings:
e Supports reductions in body fat % and waistcircumference*
Supports decreases in cholesterol and blood sugar levels*Supports reductions in C-reactive protein (inflammatorymarker)*
Source: The Use of Cissus Quadrangularis Formulation inthe Management of Weight Loss and Metabolic Syndrome

Journal: Functional Foods in Health and Disease 2020
A randomized, placebo controlled, double-blind studyinvolving 32 participants was conducted over 20 weeks toinvestigate the efcacy of |GOB131's active compound onbody fat ratio and triglyceride levels in healthy adults.
Key Findings:
e Supports visceral and subcutaneous fat loss*Supports body weight and body fat ratio reductions*eSupports reduced triglyceride levels*
Source: Efect of Ellagic Acid on Body Fat and TriglycerideReduction in Healthy Overweight Volunteers: aRandomized, Double-blind, Placebo-controlled ParallelGroup Study

Journal: Lipids in Health and Disease 2009
A randomized, double-blind, placebo controlled studyinvolving 102 participants was conducted over 10 weeks toevaluate the effects of lGOB131 on body weight andassociated metabolic parameters.
Key Findings:
Supports improvements in body weight, body fat, andwaist circumference*
Supports improvements in cholesterol and blood sugarlevels*
,Supports healthy leptin levels (a hormone that regulatessatiety)*
Source:lGOB131, a Novel Seed Extract of the West AfricanPlant lrvingia gabonensis, Signifcantly Reduces BodyWeight and lmproves Metabolic Parameters in QverweightHumans in a Randomized, Double-blind, Placebo-controlledInvestigation.

Journal: Lipids in Health and Disease 2005
A randomized, double-blind, placebo-controlled studyinvolving 40 participants was conducted over 4 weeks toevaluate the efcacy oflGOB131 seeds in the managementof metabolic factors.
Key Findings:
eSupports improved waist and hip circumference*eSupports healthy blood pressure levels*Supports a decrease in cholesterol*
Source: The Efect of lrvingia Gabonensis seeds on BodyWeight and Blood Lipids of Obese Subjects in Cameroon

Journal: Functional Foods in Health and Disease 2015
A randomized, double-blind, placebo-controlled studyinvolving 48 participants was conducted over 8 weeks toinvestigate the efects of lGOB131 in healthy participants.
Key Findings:
eSupports a reduction in body weight*Supports a reduction in BM|*Supports a decrease in cholesterol and triglycerides*
Source: The Efect of Extracts of lrvingia gabonensis(1GOB131) and Dichrostachys glomerata(Dyglomera™) onBody Weight and Lipid Parameters of Healthy OverweightParticipants

Journal: EBioMedicine 2016
A randomized, double-bind placebo-controlled studyinvolving 225 participants aged 18-65 years old wasconducted over 6 months to investigate the effects ofBifdobacterium animalis ssp. lactis 420(B420) on body fatmass and other parameters.
Key Findings:
eSupports a decrease in trunk fat mass*。Supports curbed cravings and a regulated appetite*Reduces zonulin levels (marker of disrupted gut barrierfunction)*
Source: Probiotic With or Without Fiber Controls Body FatMass, Associated With Serum Zonulin, in Overweight andObese Adults-Randomized Controlled Trial

Journal: Benefcial Microbes 2019
A randomized, double-blind, placebo-controlled studyinvolving 134 participants aged 18-65 years old wasconducted over 6 months to test if Bifdobacterium animalisssp.lactis 420 (B420) is associated with changes in gutmicrobiota.
Key Findings:
Supports increases in Akkermansia (associated withimproved metabolic health)*
Supports a healthy gut microbiome (increases the ratioof "good to bad gut bacteria")*Supports gut barrier function
Source: Probiotic or Synbiotic Alters the Gut Microbiotaand Metabolism in a Randomised Controlled Trial of WeightManagement in Overweight Adults

Journal: Nutrients 2020
An analysis of the in vitro, pre-clinical, and clinical studiesthat have investigated the effects of Bifdobacteriumanimalis ssp.lactis 420(B420) was conducted to determineits effects on gut microbiota and metabolic health.
Key Findings:
Supports improved gut barrier function*Supports an improvement in waist to hip ratio"Supports improvements in gut dysbiosis*
Source: Bifdobacterium animalis subsp. lactis 420 forMetabolic Health: Review of the Research

Journal: British Journal of Nutrition 2013
A randomized, single-blind, placebo-controlled studyinvolving 19 healthy male participants was conducted toexamine the effects of grains of paradise on whole-bodyenergy expenditure and brown adipose tissue (BAT) activity.
Key Findings:
eSupports up to a 5x increase in calories burned over 2hours*
Supports increases in metabolic rate within 30 minutesof administration*
Supports elevated metabolic rate for several hours overbaseline*
Source: Grains of paradise(Aframomum melegueta) extractactivates brown adipose tissue and increases whole-bodyenergy expenditure in men

Journal: Journal of Nutritional Science and Vitaminology 2014
A randomized, single-blind, placebo-controlled, studyinvolving 19 healthy female participants was conducted toexamine the efect of daily ingestion of grains of paradise onwhole-body energy expenditure and body fat.
Key Findings:
Supports decreases in visceral fat*Supports improved body composition* Up to 97 more calories burned per day
Source: Daily Ingestion of Grains of Paradise (Aframomummelegueta) Extract Increases Whole-Body EnergyExpenditure and Decreases Visceral Fat in Humans

Journal of Nutritional Science and Vitaminology 2021
A randomized, single-blind, placebo-controlled studyinvolving healthy male volunteers was conducted over 5weeks to investigate if grains of paradise might revive brownadipose tissue (BAT) in individuals who have lost active BAT.
Key Findings:
Supports decreases in body fat %*Can elevate adaptive thermogenesis*Supports reactivation of brown adipose tissue (BAT)*Source: Prolonged Treatment with Grains of Paradise(Aframomum melegueta) Extract Recruits AdaptiveThermogenesis and Reduces Body Fat